The Biology Mining Company
The richest data source on Earth is inside every living cell.
We’ve learned to mine it.
Everything we know about biology is built on an incomplete picture.
For decades, genetics has been the foundation of modern biology and medicine, telling us what a cell might do. But proteins tell us what it's actually doing — every drug, every disease, every threat. The proteome has been largely invisible because we lacked the technology to mine its data.
At Pumpkinseed, we created the physics to read that data directly: from individual molecules, from single cells, and from complex tissues. We shine a light on the proteome and extract life's most valuable and previously inaccessible data.
deSIPHR: A new way to read proteins
DeSIPHR is Pumpkinseed's proprietary nanophotonic chip platform. It enables direct, de novo read-out of protein identity, sequence, and modification state at single-molecule resolution. With over 100 billion sensors per wafer, deSIPHR reads the proteome using Raman spectroscopy.
No reference proteins, no elaborate sample prep, no fragmentation. Direct, high-resolution proteomic data at a scale and fidelity that simply hasn't existed before.
Biology speaks in proteins, and existing methods can only read fragments of this language. DeSIPHR illuminates the functional language of life at scale.
Applications & Partnerships
Biopharma
Reading the proteins that drugs act on, directly, de novo, and at single-molecule resolution, to accelerate target identification, mechanistic studies, and therapeutic design.
Biosecurity
Uncovering novel protein biomarkers, post-translational modifications, and low-abundance signals that database-dependent tools cannot find, including unknown biological entities no current method can detect.
Bio-AI
Generating the single-cell molecular datasets that AI biology needs to move from predicting protein structure to predicting cellular behavior.
Built to mine biological data at its source
Biology's richest seam of data has always been there — too deep and dynamic to reach. We're building a multidisciplinary team of physicists, biologists and data scientists to mine it directly at the source.
We envision a world where the molecular signatures driving disease, aging and ecosystem health are fully legible, shifting medicine from reactive to proactive.
